휴코드 HUCORD

HSCM

HSCM

About HSCM
Manufacturing Process
Key Benefits
Key Substances
Comparative Analysis
Research on Efficacy
Test Reports

About HSCM

The Source of Biotechnology: Human Cord Blood Stem Cell Conditioned Media

Hucord’s Human Cord Blood Stem Cell Conditioned Media (HSCM),
a pinnacle of advanced biotechnology, offers the promise of healthier skin and new treatment possibilities.
As a key element for a healthier future for humanity, HSCM provides a unique solution for cell regeneration and recovery.

INCI/ICID

Human Cord Blood Cell Conditioned Media

INCI Monograph ID

22749

CAS No.

871903-86-5

The Significance of HSCM

HSCM is a crucial substance derived from the culture of cord blood mesenchymal stem cells, containing 151 proteins and growth factors secreted by these stem cells. It is used in the production of pharmaceuticals for inflammation, wound healing, and skin disease treatment, as well as in the development of anti-aging and skin regeneration cosmetics.

Hucord will continue to lead the medical and cosmetics industries with its Human Cord Blood Stem Cell Conditioned Media (HSCM), developed through proprietary stem cell technology and maintained under world-class quality control and strict safety standards. The company is committed to ongoing growth through continuous research and development.

Manufacturing Process

Cord Blood Selection
Stem Cell Isolation
Stem Cell Culturing
HSCM Collection
Removal of Cellular Byproducts
Viral and Bacterial Testing
Packaging and Storage at -80°C

Key Benefits

Anti-aging Effects

01

Prevention and Recovery of UV-Induced Skin Damage and Aging

Repairs skin damage caused by UV radiation and inhibits the aging process.
02

Promotion of Cell Differentiation and Proliferation

Induces cell differentiation and proliferation to prevent aging and resist various cellular stresses.
03

Maintenance of Skin Firmness

Promotes fibroblast growth and activates matrix substances like collagen to maintain skin firmness.
04

Maintenance of Skin Homeostasis

Maintains skin’s moisture balance and regulates responses to various external environmental changes to uphold homeostasis.

Activation of Skin Regeneration

01

Hair Growth and Follicle Formation Promotion

Stimulates the formation of new hair follicles, preventing hair loss and promoting hair growth.
02

Scar Minimization

Regulates immune response during wound occurrence to minimize scar formation.
03

Promotion of Skin Cell Growth

Enhances the growth of epidermal cells and the basement membrane, aiding in the regeneration of damaged skin.
04

Wound Healing

Promotes angiogenesis, enhancing the skin’s natural healing ability for faster wound recovery.

Key Substances

Growth Factors

IGF-1: Regulates cell growth, development, and DNA synthesis; Promotes the production of collagen, elastin, and hyaluronic acid

IGFBP-3: Plays a critical role in cell growth, differentiation, and apoptosis by regulating IGF-1 function; Can be utilized for cancer suppression and treatment of various diseases

IGFBP-6: Binds to IGF-2 to regulate its physiological activities; Exhibits anti-cancer effects by inhibiting the growth of certain cancer cells

PDGF-AA: Involved in angiogenesis with VEGF; Effective for skin regeneration and hair growth

PDGF-BB: Promotes the proliferation and differentiation of various cells; Plays an essential role in wound healing and tissue regeneration

bFGF: Involved in cell growth, morphogenesis, and tissue repair; Stimulates fibroblasts to restore skin regeneration and maintain healthy skin

EGF: Stimulates cell growth and differentiation; Maintains skin firmness and stabilizes the skin

Cytokines

TIMP-1: Protects against skin damage and inhibits aging caused by matrix metalloproteinases (MMPs) during UV exposure; Increases collagen synthesis to reduce wrinkles

TIMP-2: Induces immune cells and regulates inflammatory response during tissue damage or infection; Promotes the growth of skin fibroblasts

GM-CSF: Enhances the production and function of neutrophils and macrophages,; Plays a critical role in immune and inflammatory responses.

SCF: Stimulates epithelial stem cells to induce cell differentiation and proliferation; Promotes new hair follicle formation and hair growth

IL-8: Induces immune cells and granulocytes during tissue damage and infection; Promotes wound healing by facilitating angiogenesis

IL-10: Secreted by keratinocytes during skin damage; Regulates immunity and exhibits anti-inflammatory effects

IL-18: Modulates inflammatory and cell-mediated immune responses; Applicable in treating infections, inflammatory diseases, cancer, and in vaccine development.

IP-10: Exhibits anti-inflammatory action and immune regulation; Controls inflammatory responses and prevents tissue damage

MCP-1: Attracts monocytes and macrophages to the site of inflammation, regulating immune and inflammatory responses; Plays a significant role in inflammatory diseases, cardiovascular diseases, and cancer

M-CSF: Involved in the proliferation, differentiation, and survival of macrophages; Protects the skin from microbes and environmental pollutants

MIP-1: Induces immune responses during inflammation and infection; Promotes wound healing and scar reduction

RANTES: Stimulates NK cell proliferation and activation; Maintains skin homeostasis (e.g., moisture balance) by activating G-protein coupled receptors

TGF-β1: Promotes collagen synthesis to maintain skin firmness and reduce wrinkles; Plays a crucial role in maintaining normal skin structure and function

Exosome

These are very small vesicles, about 50~200nm in size, generated by stem cells. They contain various factors, including RNA and proteins, similar to those found in stem cells, and contribute to the activation of skin cells.

Each ml contains over 1 trillion exosomes, which significantly enhance the skin’s foundational strength. This abundance of exosomes offers remarkable benefits, including environmental protection, anti-aging effects, and anti-inflammatory action.

The high content of exosomes, which are tiny nanoparticles, allows active substances to be delivered quickly and deeply into skin cells, maximizing absorption effectiveness.

Comparative Analysis

Hucord’s HSCM

Company A / Korea

Company B / USA

Company C / Japan

The graph shows that the growth factors and cytokines present in Hucord’s HSCM are 10,000 to 70,000 times higher than those found in other companies’ culture media.

Research on Efficacy: HSCM

The Impact of Hucord’s HSCM on Dermal Cell Proliferation Ability

Control Group

HSCM

Adipose Stem Cell Conditioned Media

Bone Marrow Stem Cell Conditioned Media

Dermal cells were cultured for four days in HSCM (Human Cord Blood Stem Cell Conditioned Media), adipose stem cell conditioned media, and bone marrow stem cell conditioned media, respectively. The results showed that bone marrow stem cell conditioned media led to a decrease in dermal cell proliferation compared to the control group, while adipose stem cell conditioned media resulted in approximately twice the proliferation. In contrast, HSCM demonstrated more than a fivefold increase in proliferation compared to the control group.

Comparison of Dermal Cell Proliferation Ability Between HSCM and Other Companies’ Stem Cell Conditioned Media

Control Group

HSCM

Company A (USA)

Company B (Korea)

After culturing dermal cells for four days with stem cell conditioned media from various companies, Company A (USA) showed no dermal cell proliferation, while Company B (Korea) demonstrated proliferation similar to the control group. In contrast, HSCM resulted in a significant increase in proliferation, showing over four times the growth compared to the control group.

Collagen Synthesis and Inhibition of Degradation: When Vitamin C (L-ascorbic acid), known for its superior ability to synthesize collagen, was supplied to skin dermal cells, collagen synthesis increased by 40% compared to the control group. However, when HSCM was supplied, collagen synthesis was confirmed to be over 60%, which is 20% higher than with Vitamin C.
Collagen: A protein that forms the support layer of skin cells and is crucial for skin elasticity and wrinkle improvement.

Inhibition of MMP-1 Synthesis: When dermal cells were exposed to UV radiation, MMP-1 levels increased by over 80% compared to the non-irradiated control group. However, when dermal cells were exposed to UV radiation in the presence of HSCM, the synthesis of MMP-1 was significantly reduced to 20%. This suppression of MMP-1 helps inhibit collagen breakdown in dermal cells, thereby maintaining collagen levels in the skin.
MMP-1: This is a protein that promotes collagen degradation, leading to reduced collagen levels in the skin and contributing to the formation of wrinkles.

When TIMP-1 was administered, collagen IV maintained abundant continuity along the epidermal-dermal junction and blood vessels. In contrast, the control group showed a significant reduction in collagen and a loss of continuity.